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As the technology matures, on that point are at to the lowest degree three dozen new continuous glucose monitors subordinate development. Image via Prediktor Medical

As continuous glucose monitoring (CGM) becomes a more integral part of therapy for many people with diabetes, health care technical school companies are clamoring to develop new systems to ingathering to a broad spectrum of voltage users.

We've identified at least three dozen efforts to develop new CGMs and novel meters — some of them aiming for the Blessed grail of noninvasive glucose monitoring: not needing to pierce the skin.

(This, of course, is to boot to the four CGMs currently on the market that are made by Dexcom, Medtronic, Abbott Diabetes Care, and Eversense.)

Here's a abstract snapshot of each of these aspiring new systems.

Apple

The tech giant has reportedly been functioning on a noninvasive CGM for much of the penultimate decade, with busy 30 people assigned to the jut at unitary point.

Unity of their concepts is believed to involve optical sensors, while another story from 2019 discusses Apple's unobstructed for a CGM sensor built into a smartwatch that would be able to monitor other health information A well.

Up to now, rollouts of new Malus pumila Watch technology haven't included this functionality, and Apple hasn't thus far filed anything with the Solid food and Drug Presidential term (FDA).

To be clear, this is separate from the Dexcom CGM data show available on Orchard apple tree smartwatches.

Alertgy

This Sunshine State-based startup is attempting to create a noninvasive CGM system dubbed ANICGM. It would monitor glucose readings victimisation miniaturized MRI-like engineering on a wristband.

As of November 2019, the company was recruiting people with type 2 diabetes for a clinical test at Cleveland Clinic.

Know Labs

This Seattle inauguration is attempting to create a noninvasive, wearable device dubbed the UBAND. It uses radio waves to measure glucose levels.

The company claims the system butt already detect much blood glucose, "and with the espial of white blood corpuscle levels it's possible UBAND could suit an early admonition espial scheme for cancer and disease."

Happening its FAQ page, Know Labs states that it plans to seek FDA approving in 2020.

LifePlus

This Atomic number 14 Valley–based startup is underdeveloped a noninvasive habiliment called LifeLeaf, which information technology says testament be able to detect blood sugar levels, stemma pressure, heart rate, sleep apnea, and more utilizing sensors already along the market and an additional light sensing element to enhance accuracy.

The company states it's currently conducting clinical trials around the world.

PK Vital force

This relatively new European caller is attempting to bring to market a smartwatch that can measure glucose levels and lactic pane levels. The device is said to sample mobile in the physical structure through and through small microneedles under the watch whenever the wearer pushes a push button.

Prediktor Medical

This company from Norway is developing a noninvasive armband CGM called BioMK that's apparently supported "industrial real-time measurement technology." Details are scarce, as the project is in the development stages.

i-SENS

In a late 2019 investor presentation, this Asian-based International fingerstick meter manufacturer stated that it plans to roll come out of the closet a CGM in roughly 2021.

The presentation offered few inside information of the new product, simply like-minded others in this list, the company believes it can compete in the CGM securities industry through its power to keep manufacturing costs low.

What's difficult to empathise, though, is that i-SENS has been functional on this for old age but sold some operating room altogether of an earlier CGM conception to some other company called WaveForm in December 2016; see below for more.

Pacific Diabetes Technologies

This Oregon keep company is temporary to develop a first-of-its-kind CGM with a different kind of sensor that also has a port for insulin delivery. Information technology's designed for those on insulin pump therapy operating room octuple daily injections (MDI).

The party has received JDRF financial backin through the years. Their CEO tells DiabetesMine that they hope to seek FDA review in roughly 2023.

WaveForm Technologies

This company was once part of device-maker AgaMatrix before splitting off along its own. It's developing a CGM system based (leastways in part) on technology acquired from both Bayer and i-SENS backrest in 2016.

Now onymous the Shower CGM organization, this device earned CE Saint Mark approval from European health regulators in late 2019. The CGM system includes a thin 14-day sensor and rechargeable square transmitter that sends veridical-time readings via Bluetooth to an iOS or Humanoid mobile app.

The CGM likewise offers 15-minute predictive high and low glucose alarms, strange customizable alerts, and a once-a-day calibration.

As DiabetesMine reportable in archaean 2020, WaveForm expects to file the Shower CGM with the FDA in 2020 but doesn't expect to launch this product until 2021.

POCTech

This company has partnered with fingerstick meter manufacturer Ascensia (formerly Bayer) to commercialize its CAT-100 CGM, which gained CE approval in late 2016 for European countries.

Information technology's a casebook-sized sensor and transmitter system collective for 7-day wear. Nonsubjective trial data seems to show it Crataegus laevigata be the most accurate on the market.

As DiabetesMine reported in early 2019, Ascensia was talking approximately trying to file with the Food and Drug Administration by closing 2020 happening a next-contemporaries product that's part of this atomic number 27-development agreement.

Roche Diabetes Care

The company behind the popular Accu-Chek fingerstick meter brand was rumored to be developing a CGM of its ain for umpteen long time, but it's a bite unclear whether that's still occurrence.

Roche static appears determined to bring the Alone micropump to market later on acquiring the tech from an Israeli inauguration in 2010. Information technology's teased that a next-generation interpretation will whir CGM data integrating.

IT's TBD whether that's an in-house product in development or a partnership using existing tech, like the implantable Eversense CGM.

Medtrum

This Mainland China-based companionship is developing the A6 TouchCare System, a tubeless semiautomated insulin delivery organisation that includes an incorporate CGM.

DiabetesMine previously reported on the "tiny, flexible, hair's-breadth-like sensor that would last 7 days and put up a prophetic down-glucose suspend boast." This YouTube television also offers a coup d'oeil of what this sensor and snap-happening transmitter look like.

Per an early 2019 reputation, the A6 TouchCare system has been in European nonsubjective trials since then.

SanaVita Medical

SanaVita has entered into a partnership with LifeScan, the maker of the Indefinite Touch brand of fingerstick meters, to bring a CGM to securities industry in N America and some Continent countries.

Piece there are a couple of details of the proposed SanaVita OneTouch Realistic Time Continuous Glucose Monitoring System, a pilot clinical trial is regular to take place in early 2020.

Glucovation

This San Diego startup, supported aside former Dexcom alums, has been developing a product called SugarSenz, represented as a extremely accurate, low-cost wearable CGM.

The company and Dexcom settled lawsuits terminated intellectual property rights in 2016. Since then, there hasn't been much public discussion of this new tech.

However, company images of the SugarSenz cartesian product evidenc a round sensor transmitter concept. Think FreeStyle Libre with a big X crosswise the top.

Infinovo

This Chinese company has created the Glunovo i3 CGM, which features a sensing element similar in size to the Dexcom sensors that can be shabby for up to 14 days.

The CGM has been granted a CE mark in 2019 and is expected to enter the European marketplace soon.

GlucoRx

This U.K. company appears to equal rebranding a CGM organisation from MicroTech Medical, which uses a traditional sensing element to deliver readings to a smartphone.

The system appears to offer goad-free insertion, reusable sensor applicators, and brief warmup time, although confirmed details about the in-development product are scarce.

Integrated Medical Sensors

This inauguration out of Irvine, California, was born exterior of enquiry at the California Institute of Technology. Information technology's developing an implantable CGM the size of a sesame seed.

Seriously, it's so small it could easily get lost along the tip of a fingerbreadth or the face of a penny, and IT will last below the skin for as long as 6 to 9 months.

Just this week, the troupe volition be presenting at the big European diabetes conference ATTD, showing information technology got its MARD grudge (measure of CGM accuracy) blue to impressive levels.

Profusa

This company is working to develop implantable sensors supported its proprietary Lumee Oxygen program that could continually monitor glucose readings and other biomarkers.

The device would be a 10th of an inch sesquipedalian and would cost injected under the skin, where it could stay and be used for up to 2 years.

The company has received funding from the U.S. Ground forces, Defense Advanced Research Projects Agency, and NIH for its work.

Metronom Wellness

A past Ascensia Diabetes Challenge Winner, this Belgique-based company hopes to bring off to market a haircloth-thick sensor that can be haggard nether the clamber for 14 days and communicate to smartphone apps via a relatively small, disposable transmitter.

The in-evolution sensor would be fit to strain some environmental inputs that can tether to inaccurate glucose readings in other CGMs.

Finally report card, the company was hoping to get before Food and Drug Administration regulators away first 2020, simply that doesn't appear to have happened up to now.

GluSense

This Land troupe is attempting to create an implantable CGM that uses an encapsulated fluorescent glucose sensor that can personify deep-seated for heavenward to a twelvemonth.

In 2017, the company received $2 zillion in JDRF funding to help with the growth of the twist, and IT's largely been in stealth mode since then.

When we talked with a company EXEC at the ADA Scientific Sessions in June 2019, helium shared that they're writhing impudent along early clinical work, and they may still be a few long time out from being ready to submit to regulators.

We may hear more from GluSense in 2020, though, so stay attuned.

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The GluSense sensor. Image via DiabetesMine

GlySens

This San Diego–supported company is developing an implantable CGM called the ICGM that could be scoured under the hide for a twelvemonth or longer.

The system includes a transmitter worn outwardly that would relay readings to a smartphone. It's organism designed to require infrequent calibration.

The ICGM is currently being evaluated in initial human clinical trials.

PercuSense

The goal of this Southern California–founded fellowship is to create an implantable CGM that doesn't require calibration and utilizes an electromagnetic point to measure glucose.

The startup has recently partnered with European pump-maker Diabeloop and SFC Fluidics on a JDRF-sponsored project.

Biolinq

This San Diego company is developing a nickel-sized, acerate leaf-unconstrained CGM that includes a reversible battery and intrinsical transmitter that would monitor glucose trends and other biomarkers.

DiabetesMine profiled Biolinq in fall 2019. While this startup's been around for many eld, IT's had an uptick in interest recently after receiving $4.75 million in backing from the JDRF's T1D Fund and establishing original leading from within the diabetes community.

The startup is prospective at least a mate years out from bringing this product to the commercialization stage.

Nemaura Medical

This U.K. company recently acceptable Cerium mark approval for its SugarBEAT CGM product, a patch sensor that utilizes a mild electrical current to run small amounts of glucose from under the skin.

A transmitter sends wireless readings to a smartphone app all 5 minutes, and the system can predict glucose readings up to 20 minutes in advance.

While not rather as veracious arsenic the stylish Dexcom CGM, the company predicts its system will cost just unrivalled-fifth of competing mathematical product prices.

Nemaura Medical examination is launching internationally and submitted SugarBEAT to the FDA in July 2019, where it remains pending before regulators.

GraphWear Technologies

For the terminal a couple of years, this San Francisco–founded company has been working to educate a continuous piece detector that can observe biomarkers, including glucose, through and through sudor.

There are fewer details, but IT appears the company is gearing its continuous sensing element toward a broad health market, not just toward the handling of diabetes.

Medtronic

In for, this company had the first CGM on the securities industry and is one of the four biggies currently available. That doesn't tight it isn't planning for the hereafter with novel new CGM concepts.

The diabetes tech hulk filed a plain in September 2018 for a glucose monitoring patch that would change colours based on glucose readings taken over past sweat.

Patents, all the same, often wear't lead to products. There appears to be no further public details about the project since then.

Sano

This San Francisco company is endeavoring to make a patch biosensor that rear deliver readings for live stats that admit glucose levels.

The circular speckle device geared toward the non-diabetes mainstream wellness market made life-sized news in 2018 afterward Fitbit invested with $6 jillio into the idea, only it hasn't sparked much attention after that.

University of California, San Diego

Researchers are testing whether a passing tattoo with integrated thin and flexible sensors can put up accurate glucose readings from sweat. A pilot study concluded in June 2019.

AnnNIGM

Details are scarce in English, but this Country fellowship appears to be attempting to evolve a time that can follow worn as an ear clip.

Integrity Applications

This company recently acceptable the C.E. fall guy from Continent regulators for a person-calibrating adaptation of GlucoTrack, its noninvasive glucose monitoring device.

This twist clips to the ear and uses a combination of ultrasonic, electromagnetic, and fountain technologies to measure glucose levels.

EasyGlucose

This student-LED initiative KO'd of UCLA is focused on developing a agency to monitor glucose levels through imagery of the retina.

A special lens would constitute pasted to a smartphone photographic camera to monitor subtle changes in the retina to discover glucose levels in the body. The concept South Korean won Microsoft's Imagine Loving cup in 2018.

NovioSense

This wellness tech keep company from Holland is attempting to bring to market a CGM that can beat glucose done weeping.

The device would rest in the lower eyelid. The ship's company conducted a small clinical trial of the device in people with type 2 diabetes in 2018.

CNOGA Medical

This Israeli company has created a CGM dubbed CoG that offers stripped fingerpricks. The hybrid device, which utilizes fingerprick readings for initial calibration and light-emitting diodes for noninvasive readings, has been awarded CE mu approval.

The company is currently working on receiving FDA approval.

DiaMonTech

This European country caller is developing a noninvasive CGM system that utilizes an infrared beam to tally glucose molecules under the skin.

The ship's company conducted a triple-crown hominid clinical test in 2019 and hopes to launch its ware in 2020.

Coloured Diabetes

This Belgian company is attempting to develop a noninvasive CGM that would use photonic light to measure glucose levels. The company was featured at the J.P. Sir Henry Morgan 2020 Health care Group discussion.

MTI

This U.K. company is nonindustrial GlucoWise, a noninvasive glucose monitoring device that would use radio waves to measure glucose levels.

The device has been under development for some time. In 2017, results of a human run cooked unitedly with the University of Roehampton were published in the journal Nature. In 2018, they published results of an animal trial (pigs) that showcased the sensitivity of the system.

The University of Waterloo

Researchers have described a cogent evidence-of-concept system that would utilize radar technology from Google to measure glucose levels in a solution.

The goal, course, would be to use this technology to create a device that can measure glucose levels in the body.

The University of Bath

U.K. researchers are attempting to create a thin, graphene-based glucose sensing element. IT would use an array of miniature sensors utilizing a small electric current to draw glucose verboten from the opening fluid that's located between cells inside the body's hair follicles.

The companion explains that each sensing element covers an individual follicle. Measurements could exist taken every 10 to 15 minutes and transmitted to an app.

After successful lab tests, the researchers hope to begin examination the device in a human medical institution trial.

Echo Therapeutics

Finally, for Sir Thomas More than a tenner (at least), this company has been talking about building a noninvasive CGM that could track glucose levels through the skin.

That's ne'er materialized, but the once-called Symphony product reemerges all so often with hope and support pitches.

Last we heard in 2016, the keep company had emotional to New Jersey and rebranded its CGM concept American Samoa the NextGen, only it was still only in early phases of explore and development.

Information technology still comes to mind by industriousness observers when mentioning CGM wannabes.